Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway

Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway

We identified the effective components and the underlying mechanisms of Quince (Cydonia oblonga Mill, COM) extract against atherosclerosis. The effective components of COM extract were identified with UHPLC-Q-TOF-MS/MS. Network pharmacology was performed. A rat model of atherosclerosis induced by hi...

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Bibliographic Details
Main Authors: Abulaiti Abulizi, Jimilihan Simayi, Maimaitiming Nuermaimaiti, Mengyuan Han, Sendaer Hailati, Ziruo Talihati, Nulibiya Maihemuti, Muhadaisi Nuer, Nawaz Khan, Kayisaier Abudurousuli, Dilihuma Dilimulati, Nuerbiye Nueraihemaiti, Nicholas Moore, Wenting Zhou, Ainiwaer Wumaier
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Quince
Atherosclerosis
Serum pharmacochemistry
Network pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222300118X

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http://www.sciencedirect.com/science/article/pii/S075333222300118X

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