miR-1246 in tumor extracellular vesicles promotes metastasis via increased tumor cell adhesion and endothelial cell barrier destruction

miR-1246 in tumor extracellular vesicles promotes metastasis via increased tumor cell adhesion and endothelial cell barrier destruction

BackgroundTumor blood vessels play a key role in tumor metastasis. We have previously reported that tumor endothelial cells (TECs) exhibit abnormalities compared to normal endothelial cells. However, it is unclear how TECs acquire these abnormalities. Tumor cells secrete extracellular vesicles (EVs)...

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Bibliographic Details
Main Authors: Masahiro Morimoto, Nako Maishi, Takuya Tsumita, Mohammad Towfik Alam, Hiroshi Kikuchi, Yasuhiro Hida, Yusuke Yoshioka, Takahiro Ochiya, Dorcas A. Annan, Ryo Takeda, Yoshimasa Kitagawa, Kyoko Hida
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
miRNA
extracellular vesicles
metastasis
tumor endothelial cell
VE-cadherin
ICAM-1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.973871/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.973871/full

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