TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1

TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1

Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory periodic fever syndrome associated with heterozygous mutations in TNFRSF1A, which encodes TNF receptor type I (TNFR1). Although possible proinflammatory mechanisms have been proposed, most previous studi...

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Bibliographic Details
Main Authors: Takahiko Akagi, Sumie Hiramatsu-Asano, Kenta Ikeda, Hiroyasu Hirano, Shoko Tsuji, Ayano Yahagi, Masanori Iseki, Makoto Matsuyama, Tak W. Mak, Kazuhisa Nakano, Katsuhiko Ishihara, Yoshitaka Morita, Tomoyuki Mukai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
tumor necrosis factor-α
TNF receptor-associated periodic syndrome
TNF receptor 1
murine model
autoinflammatory disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.926175/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.926175/full

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