Molecular homing and retention of muscle membrane stabilizing copolymers by non-invasive optical imaging in vivo

Molecular homing and retention of muscle membrane stabilizing copolymers by non-invasive optical imaging in vivo

First-in-class membrane stabilizer Poloxamer 188 (P188) has been shown to confer membrane protection in an extensive range of clinical conditions; however, elements of the systemic distribution and localization of P188 at the organ, tissue, and muscle fiber levels in vivo have not yet been elucidate...

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Bibliographic Details
Main Authors: Addeli Bez Batti Angulski, Houda Cohen, Mihee Kim, Dongwoo Hahn, Nicholas Van Zee, Timothy P. Lodge, Marc A. Hillmyer, Benjamin J. Hackel, Frank S. Bates, Joseph M. Metzger
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
synthetic block copolymers
Poloxamer 188
membrane stabilizer
Duchenne muscular dystrophy
dystrophin-deficient mdx mice
damaged muscle membrane
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001784

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http://www.sciencedirect.com/science/article/pii/S2329050122001784

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