Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice

Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice

Malaria remains a global health challenge, necessitating the development of effective vaccines. The RTS,S vaccination prevents Plasmodium falciparum (Pf) malaria but is ineffective against Plasmodium vivax (Pv) disease. Herein, we evaluated the murine immunogenicity of a recombinant PvCSP incorporat...

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Bibliographic Details
Main Authors: Tiffany B. L. Costa-Gouvea, Katia S. Françoso, Rodolfo F. Marques, Alba Marina Gimenez, Ana C. M. Faria, Leonardo M. Cariste, Mariana R. Dominguez, José Ronnie C. Vasconcelos, Helder I. Nakaya, Eduardo L. V. Silveira, Irene S. Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
adjuvant
TLR3-ligand
malaria
antibody-secreting cells
memory B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1331474/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1331474/full

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