Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization

Abstract Ion channels function within a membrane environment characterized by dynamic lipid compartmentalization. Limited knowledge exists regarding the response of voltage-gated ion channels to transmembrane potential within distinct membrane compartments. By leveraging fluorescence lifetime imagin...

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Bibliographic Details
Main Authors: Lucas J. Handlin, Gucan Dai
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42363-7