A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>

A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>

ABSTRACT Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve Cdc50, the regulatory subunit of lipid f...

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Bibliographic Details
Main Authors: Chengjun Cao, Yina Wang, Seema Husain, Patricia Soteropoulos, Chaoyang Xue
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mBio
Subjects:
antifungal drug resistance
calcium signaling
Cryptococcus neoformans
fungi
lipid flippase
Online Access:https://journals.asm.org/doi/10.1128/mBio.01952-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01952-19

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