USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target

USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target

Abstract An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a dynamic protein bidirectional modification regulation system. Deubiquitinating enzymes (DUBs) are tasked with...

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Bibliographic Details
Main Authors: Shuang Li, Yang Song, Kexin Wang, Guoxiang Liu, Xiaolei Dong, Fanghao Yang, Guang Chen, Can Cao, Huhu Zhang, Mengjun Wang, Ya Li, Teng Zeng, Chunyan Liu, Bing Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01629-1

Internet

https://doi.org/10.1038/s41420-023-01629-1

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