Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons

Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons

Monoamine neurotransmitter abundance affects motor control, emotion, and cognitive function and is regulated by monoamine oxidases. Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Loss-of-function mutations...

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Bibliographic Details
Main Authors: Jon-Ruben van Rhijn, Yan Shi, Maren Bormann, Britt Mossink, Monica Frega, Hatice Recaioglu, Marina Hakobjan, Teun Klein Gunnewiek, Chantal Schoenmaker, Elizabeth Palmer, Laurence Faivre, Sarah Kittel-Schneider, Dirk Schubert, Han Brunner, Barbara Franke, Nael Nadif Kasri
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Neurobiology of Disease
Subjects:
Brunner syndrome
MAOA
Human iPSC
Dopaminergic neuron
NMDA receptor
Microelectrode array
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121003363

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121003363

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