Carvacrol Attenuates Diabetic Cardiomyopathy by Modulating the PI3K/AKT/GLUT4 Pathway in Diabetic Mice

Carvacrol Attenuates Diabetic Cardiomyopathy by Modulating the PI3K/AKT/GLUT4 Pathway in Diabetic Mice

Background: Diabetic cardiomyopathy (DCM), a common complication of diabetes mellitus, eventually leads to heart failure. Carvacrol is a food additive with diverse bioactivities. We aimed to study the protective effects and mechanisms of carvacrol in DCM.Methods: We used a streptozotocin-induced and...

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Bibliographic Details
Main Authors: Ning Hou, Yunpei Mai, Xiaoxia Qiu, Wenchang Yuan, Yilang Li, Chengfeng Luo, Yun Liu, Guiping Zhang, Ganjiang Zhao, Jian-dong Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
diabetes mellitus
cardiac remodelling
carvacrol
cardiac function
PI3K/AKT pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00998/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00998/full

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