Insights into the molecular mechanisms underlying mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms

Insights into the molecular mechanisms underlying mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms

The mammalian P2X7 receptors (P2X7Rs), a member of the ionotropic P2X receptor family with distinctive functional properties, play an important part in mediating extracellular ATP signaling in health and disease. A clear delineation of the molecular mechanisms underlying the key receptor properties...

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Bibliographic Details
Main Authors: Lin-Hua eJiang, jocelyn eBaldwin, Sébastien eRoger, Stephen eBaldwin
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Pharmacology
Subjects:
ion channel
P2X7 receptor
Structural modeling
ATP binding
large pore
extracellular ATP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00055/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00055/full

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