Single‐cell RNA Sequencing Identified Novel Nr4a1+ Ear2+ Anti‐Inflammatory Macrophage Phenotype under Myeloid‐TLR4 Dependent Regulation in Anti‐Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN)

Single‐cell RNA Sequencing Identified Novel Nr4a1+ Ear2+ Anti‐Inflammatory Macrophage Phenotype under Myeloid‐TLR4 Dependent Regulation in Anti‐Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN)

Abstract Previously, this study demonstrates the critical role of myeloid specific TLR4 in macrophage‐mediated progressive renal injury in anti‐glomerular basement membrane (anti‐GBM) crescentic glomerulonephritis (cGN); however, the underlying mechanism remains largely unknown. In this study, singl...

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Bibliographic Details
Main Authors: Jiaoyi Chen, Xiao Ru Huang, Fuye Yang, Wai Han Yiu, Xueqing Yu, Sydney C. W. Tang, Hui Yao Lan
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Advanced Science
Subjects:
anti‐GBM crescentic glomerulonephritis
macrophages
myeloid‐TLR4
Nr4a1/Ear2
Online Access:https://doi.org/10.1002/advs.202200668

Internet

https://doi.org/10.1002/advs.202200668

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