CRISPR-Cas9-Mediated Correction of <i>SLC12A3</i> Gene Mutation Rescues the Gitelman’s Disease Phenotype in a Patient-Derived Kidney Organoid System

CRISPR-Cas9-Mediated Correction of <i>SLC12A3</i> Gene Mutation Rescues the Gitelman’s Disease Phenotype in a Patient-Derived Kidney Organoid System

The aim of this study is to explore the possibility of modeling Gitelman’s disease (GIT) with human-induced pluripotent stem cell (hiPSC)-derived kidney organoids and to test whether gene correction using CRISPR/Cas9 can rescue the disease phenotype of GIT. To model GIT, we used the hiPSC line CMCi0...

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Bibliographic Details
Main Authors: Sun Woo Lim, Xianying Fang, Sheng Cui, Hanbi Lee, Yoo Jin Shin, Eun Jeong Ko, Kang In Lee, Jae Young Lee, Byung Ha Chung, Chul Woo Yang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
Gitelman’s disease
CRISPR/Cas9
induced pluripotent stem cells
kidney organoid
Online Access:https://www.mdpi.com/1422-0067/24/3/3019

Internet

https://www.mdpi.com/1422-0067/24/3/3019

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