Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity

Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity

High fat diet (HFD)-induced obesity leads to perturbation in the storage function of white adipose tissue (WAT) resulting in deposition of lipids in tissues ill-equipped to deal with this challenge. The role of insulin like growth factor-1 (IGF-1) in the systemic and organ-specific responses to HFD...

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Bibliographic Details
Main Authors: Helen Imrie, Hema Viswambharan, Natalie J Haywood, Katherine I Bridge, Nadira Y Yuldasheva, Stacey Galloway, Katie J Simmons, Richard M Cubbon, Piruthivi Sukumar, Nicole T Watt, Laeticia Lichtenstein, Judy I Wyatt, Hiromi Kudo, Robert Goldin, Baptiste Rode, Stephen B Wheatcroft, Mark T Kearney
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Adipocyte
Subjects:
Adipocyte
insulin‐like growth factor (IGF)
lipodystrophy
obesity
browning
Online Access:https://www.tandfonline.com/doi/10.1080/21623945.2022.2089394

Internet

https://www.tandfonline.com/doi/10.1080/21623945.2022.2089394

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