Activation of Microbiota Sensing – Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis

Activation of Microbiota Sensing – Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis

Multiple emerging evidence indicates that the gut microbiota contributes to the pathology of Alzheimer’s disease (AD)—a debilitating public health problem in older adults. However, strategies to beneficially modulate gut microbiota and its sensing signaling pathways remain largely unknown. Here, we...

Full description

Bibliographic Details
Main Authors: Atefeh Razazan, Prashantha Karunakar, Sidharth P. Mishra, Shailesh Sharma, Brandi Miller, Shalini Jain, Hariom Yadav
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
microbiota
free fatty acid
G-coupled protein receptor
FFAR2 (GPR43)
fenchol
natural compounds
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.735933/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.735933/full

Similar Items