Comprehensive detection of CRLF2 alterations in acute lymphoblastic leukemia: a rapid and accurate novel approach

Comprehensive detection of CRLF2 alterations in acute lymphoblastic leukemia: a rapid and accurate novel approach

Introduction: Acute lymphoblastic leukemia (ALL) is a prevalent childhood cancer with high cure rate, but poses a significant medical challenge in adults and relapsed patients. Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype, with approximately half of cases chara...

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Main Authors: José Vicente Gil, Alberto Miralles, Sandra de las Heras, Esperanza Such, Gayane Avetisyan, Álvaro Díaz-González, Marta Santiago, Carolina Fuentes, José María Fernández, Pilar Lloret, Irene Navarro, Pau Montesinos, Marta Llop, Eva Barragán
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
acute lymphoblastic leukemia
Ph-like ALL
CRLF2 overexpression
CRLF2 variants
JAK2 variants
RT-qPCR-SYBR-HRM
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1362081/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2024.1362081/full

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