De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells

De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells

In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells. This involved the synthesis and characterization of two series of compounds namely, 1-(3-(2,6-dime...

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Bibliographic Details
Main Authors: Akshay Ravish, Rashmi Shivakumar, Zhang Xi, Min Hee Yang, Ji-Rui Yang, Ananda Swamynayaka, Omantheswara Nagaraja, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Gautam Sethi, Kwang Seok Ahn, Peter E. Lobie, Basappa Basappa
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Bioengineering
Subjects:
human breast cancer
STAT3
imidazopyridine
pyrazolines
DFT
de novo design
Online Access:https://www.mdpi.com/2306-5354/10/2/159

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https://www.mdpi.com/2306-5354/10/2/159

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