Association of catechol-O-methyltransferase gene polymorphisms with treatment response and levodopa-induced complications in Parkinson's disease: A summary of current knowledge

Association of catechol-O-methyltransferase gene polymorphisms with treatment response and levodopa-induced complications in Parkinson's disease: A summary of current knowledge

Catechol-O-methyltransferase (COMT) is one of the cardinal enzymes in the degradation of catecholamines and levodopa. Genetic variants of the COMT gene may affect COMT enzyme activity. The most examined COMT gene polymorphism is the nonsynonymous single nucleotide polymorphism (SNP) in exon 4 (Val10...

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Bibliographic Details
Main Authors: Radojević Branislava S., Jančić Ivan, Savić Miroslav M., Kostić Vladimir S., Dragašević-Mišković Nataša T.
Format: Article
Language:srp
Published: Pharmaceutical Association of Serbia, Belgrade, Serbia 2024-01-01
Series:Arhiv za farmaciju
Subjects:
parkinson's disease
levodopa-induced dyskinesia
hallucinations
comt gene
single nucleotide polymorphisms
val158met (rs4680)
Online Access:https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401023R.pdf

Internet

https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401023R.pdf

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