Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats

Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats

Background: Food-drug interaction can decrease drug effectiveness or increase risk of drug toxicity. Simvastatin is widely used for treatment of hypercholesterolemia and hypertriglyceridemia. Therefore, this study aimed to investigate the effects of pomelo juice on the pharmacokinetics of simvastati...

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Bibliographic Details
Main Authors: Kritsakorn Rayasilp, Piyanuch Wonganan, Pajaree Chariyavilaskul, Nuntaporn Prompila, Varumporn Sukkummee, Supeecha Wittayalertpanya
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2019-12-01
Series:Pharmaceutical Sciences
Subjects:
drug
food
interaction
rat
simvastatin
simvastatin acid
Online Access:https://ps.tbzmed.ac.ir/PDF/Pharm-32798

Internet

https://ps.tbzmed.ac.ir/PDF/Pharm-32798

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