Low endotoxin E. coli strain-derived plasmids reduce rAAV vector-mediated immune responses both in vitro and in vivo

Low endotoxin E. coli strain-derived plasmids reduce rAAV vector-mediated immune responses both in vitro and in vivo

The major challenge of recombinant adeno-associated virus (rAAV) vectors is host immunological barriers. Compared to the neutralizing antibody and the cytotoxic T lymphocyte response, the host immune responses induced by unsatisfactory rAAV manufacturing were largely ignored previously. rAAV vector...

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Bibliographic Details
Main Authors: Qingyun Zheng, Tianyi Wang, Xiangying Zhu, Xiao Tian, Chen Zhong, Guolin Chang, Gai Ran, Yilin Xie, Bing Zhao, Liqing Zhu, Chen Ling
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
rAAV vector production
lipopolysaccharide
NF-κB signal pathway
ClearColi technology
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012100111X

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http://www.sciencedirect.com/science/article/pii/S232905012100111X

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