Macrophage metallothioneins participate in the antileishmanial activity of antimonials

Macrophage metallothioneins participate in the antileishmanial activity of antimonials

Host cell functions that participate in the pharmacokinetics and pharmacodynamics (PK/PD) of drugs against intracellular pathogen infections are critical for drug efficacy. In this study, we investigated whether macrophage mechanisms of xenobiotic detoxification contribute to the elimination of intr...

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Bibliographic Details
Main Authors: Deninson Alejandro Vargas, David J. Gregory, Roni Nitzan Koren, Dan Zilberstein, Ashton Trey Belew, Najib M. El-Sayed, María Adelaida Gómez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Parasitology
Subjects:
metallothioneins
metal transcription factor-1 (MTF-1)
leishmania
antimony
host-parasite interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fpara.2023.1242727/full

Internet

https://www.frontiersin.org/articles/10.3389/fpara.2023.1242727/full

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