Bile salt inhibition of host cell damage by Clostridium difficile toxins.

Virulent Clostridium difficile strains produce toxin A and/or toxin B that are the etiological agents of diarrhea and pseudomembranous colitis. Treatment of C. difficile infections (CDI) has been hampered by resistance to multiple antibiotics, sporulation, emergence of strains with increased virulen...

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Bibliographic Details
Main Authors: Charles Darkoh, Eric L Brown, Heidi B Kaplan, Herbert L DuPont
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3823588?pdf=render