GenHap: a novel computational method based on genetic algorithms for haplotype assembly

GenHap: a novel computational method based on genetic algorithms for haplotype assembly

Abstract Background In order to fully characterize the genome of an individual, the reconstruction of the two distinct copies of each chromosome, called haplotypes, is essential. The computational problem of inferring the full haplotype of a cell starting from read sequencing data is known as haplot...

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Bibliographic Details
Main Authors: Andrea Tangherloni, Simone Spolaor, Leonardo Rundo, Marco S. Nobile, Paolo Cazzaniga, Giancarlo Mauri, Pietro Liò, Ivan Merelli, Daniela Besozzi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Bioinformatics
Subjects:
Haplotype assembly
Future-generation sequencing
Genetic algorithms
Combinatorial optimization
Weighted minimum error correction problem
Online Access:http://link.springer.com/article/10.1186/s12859-019-2691-y

Internet

http://link.springer.com/article/10.1186/s12859-019-2691-y

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