Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease

Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease

B cells express an antigen‐specific B‐cell receptor (BCR) and may contribute to liver inflammation by recognizing shared antigens in the gut and liver. Herein, we used high‐throughput BCR sequencing of the immunoglobulin heavy chain, specifically the complementarity‐determining region 3 (CDR3), to c...

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Bibliographic Details
Main Authors: Brian K. Chung, Eva Kristine Klemsdal Henriksen, Kristin Kaasen Jørgensen, Tom H. Karlsen, Gideon M. Hirschfield, Evaggelia Liaskou
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2018-08-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1200

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https://doi.org/10.1002/hep4.1200

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