Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease
B cells express an antigen‐specific B‐cell receptor (BCR) and may contribute to liver inflammation by recognizing shared antigens in the gut and liver. Herein, we used high‐throughput BCR sequencing of the immunoglobulin heavy chain, specifically the complementarity‐determining region 3 (CDR3), to c...
Main Authors: | Brian K. Chung, Eva Kristine Klemsdal Henriksen, Kristin Kaasen Jørgensen, Tom H. Karlsen, Gideon M. Hirschfield, Evaggelia Liaskou |
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Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Health/LWW
2018-08-01
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Series: | Hepatology Communications |
Online Access: | https://doi.org/10.1002/hep4.1200 |
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