sFgl2 gene-modified MSCs regulate the differentiation of CD4+ T cells in the treatment of autoimmune hepatitis

sFgl2 gene-modified MSCs regulate the differentiation of CD4+ T cells in the treatment of autoimmune hepatitis

Abstract Background Autoimmune hepatitis (AIH) is a T-cell-mediated autoimmune liver disease that can lead to liver injury and has a poor long-term prognosis. Mesenchymal stromal cells (MSCs) have immunosuppressive effects and can treat AIH. CD4+ T cells express the unique inhibitory Fcγ receptor (F...

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Bibliographic Details
Main Authors: Wenbin Ji, Weiwei Wang, Peiyuan Li, Yanhong Liu, Baotong Zhang, Feng Qi
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Stem Cell Research & Therapy
Subjects:
Autoimmune hepatitis
Mesenchymal stem cell
Soluble fibrinogen-like protein 2
Fcγ receptor IIB
CD4+ T cell
Online Access:https://doi.org/10.1186/s13287-023-03550-x

Internet

https://doi.org/10.1186/s13287-023-03550-x

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