A comparison of methods for detecting DNA methylation from long-read sequencing of human genomes

A comparison of methods for detecting DNA methylation from long-read sequencing of human genomes

Abstract Background Long-read sequencing can enable the detection of base modifications, such as CpG methylation, in single molecules of DNA. The most commonly used methods for long-read sequencing are nanopore developed by Oxford Nanopore Technologies (ONT) and single molecule real-time (SMRT) sequ...

Full description

Bibliographic Details
Main Authors: Brynja D. Sigurpalsdottir, Olafur A. Stefansson, Guillaume Holley, Doruk Beyter, Florian Zink, Marteinn Þ. Hardarson, Sverrir Þ. Sverrisson, Nina Kristinsdottir, Droplaug N. Magnusdottir, Olafur Þ. Magnusson, Daniel F. Gudbjartsson, Bjarni V. Halldorsson, Kari Stefansson
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-024-03207-9

Internet

https://doi.org/10.1186/s13059-024-03207-9

Similar Items