Fatty Acid Induced Hypermethylation in the <i>Slc2a4</i> Gene in Visceral Adipose Tissue Is Associated to Insulin-Resistance and Obesity

Fatty Acid Induced Hypermethylation in the <i>Slc2a4</i> Gene in Visceral Adipose Tissue Is Associated to Insulin-Resistance and Obesity

De novo lipogenesis (DNL) in visceral adipose tissue (VAT) is associated with systemic insulin sensitivity. DNL in VAT is regulated through ChREBP activity and glucose uptake through Glut4 (encoded by <i>Slc2a4</i>). <i>Slc2a4</i> expression, ChREBP activity, and DNL are decr...

Full description

Bibliographic Details
Main Authors: Jan H. Britsemmer, Christin Krause, Natalie Taege, Cathleen Geißler, Nuria Lopez-Alcantara, Linda Schmidtke, Alison-Michelle Naujack, Jonas Wagner, Stefan Wolter, Oliver Mann, Henriette Kirchner
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Slc2a4</i>
DNA methylation
human visceral adipose tissue
insulin resistance
diet-induced obese mice
Online Access:https://www.mdpi.com/1422-0067/24/7/6417

Internet

https://www.mdpi.com/1422-0067/24/7/6417

Similar Items