Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1<i>H</i>)-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90

Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1<i>H</i>)-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90

In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90 inhibitors, we designed and synthesized a novel series of 3-(heteroaryl)quinolin-2(1<i>H</i>), of types <b>3</b>, <b>4</b>, and <b>5</b>, as a novel class of analogues. A P...

Full description

Bibliographic Details
Main Authors: Enrique L. Larghi, Alexandre Bruneau, Félix Sauvage, Mouad Alami, Juliette Vergnaud-Gauduchon, Samir Messaoudi
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
Hsp90
6BrCaQ
3-(heteroaryl)quinolin-2(1<i>H</i>)-ones
purines
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/27/2/412

Internet

https://www.mdpi.com/1420-3049/27/2/412

Similar Items