The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR

The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR

Nerve Growth Factor (NGF), the prototype of the neurotrophin family, stimulates morphological differentiation and regulates neuronal gene expression by binding to TrkA and p75NTR receptors. It plays a critical role in maintaining the function and phenotype of peripheral sensory and sympathetic neuro...

Full description

Bibliographic Details
Main Authors: Sonia Covaceuszach, Doriano Lamba
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biology
Subjects:
NGF proNGF
p75NTR
pain
HSAN V
R100W mutation
molecular dynamics simulation
Online Access:https://www.mdpi.com/2079-7737/12/3/364

Internet

https://www.mdpi.com/2079-7737/12/3/364

Similar Items