Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta1-42 in mice

Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta1-42 in mice

Abstract Background Amyloid-β1-42 (Aβ1-42) plays an essential role in the development of the early stage of Alzheimer’s disease (AD). Asiatic acid (AA), an active compound in Centella asiatica L, exhibit neuroprotective properties in previous studies. Due to its low bioavailability, the nose-to-brai...

Full description

Bibliographic Details
Main Authors: Ridho Islamie, Su Lwin Lwin Myint, Tissana Rojanaratha, Garnpimol Ritthidej, Oraphan Wanakhachornkrai, Onsurang Wattanathamsan, Ratchanee Rodsiri
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Asiatic acid
SLNs
Nose-to-brain
Amyloid beta
Memory dysfunction
Mice
Online Access:https://doi.org/10.1186/s12906-023-04125-2

Internet

https://doi.org/10.1186/s12906-023-04125-2

Similar Items