Anti-PCSK9 monoclonal antibody attenuates high-fat diet and zymosan-induced vascular inflammation in C57BL/6 mice by modulating TLR2/NF-ƙB signaling pathway

Anti-PCSK9 monoclonal antibody attenuates high-fat diet and zymosan-induced vascular inflammation in C57BL/6 mice by modulating TLR2/NF-ƙB signaling pathway

Objective(s): Excess intake of a high-fatty diet (HFD) together with zymosan administration mediates vasculitis response which leads to impaired serum lipid levels and causes arterial stiffness. In the development of new cholesterol-lowering medications, PCSK9 inhibitor (proprotein convertase subtil...

Full description

Bibliographic Details
Main Authors: Priyanka Arya, Uma Bhandari, Kalicharan Sharma, Priyanka Bansal
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-05-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
anti-pcsk9 antibody
high-fat diet
inflammation
toll-like receptor
zymosan
Online Access:https://ijbms.mums.ac.ir/article_20184_08cc21fdddef2aacc5bad6fe66520795.pdf

Internet

https://ijbms.mums.ac.ir/article_20184_08cc21fdddef2aacc5bad6fe66520795.pdf

Similar Items