Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes

Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes

Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection of human DRGs. DRG eQTLs were enriched within untranslated regions of c...

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Bibliographic Details
Main Authors: Marc Parisien, Samar Khoury, Anne-Julie Chabot-Doré, Susana G. Sotocinal, Gary D. Slade, Shad B. Smith, Roger B. Fillingim, Richard Ohrbach, Joel D. Greenspan, William Maixner, Jeffrey S. Mogil, Inna Belfer, Luda Diatchenko
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
dorsal root ganglion
DRG
single nucleotide polymorphism
SNPs
expression quantitative trait loci
eQTLs
genome-wide association study
GWAS
quantitative sensory testing
QST
pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306435

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http://www.sciencedirect.com/science/article/pii/S2211124717306435

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