Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis

Aging is associated with impairments in learning, memory, and cognitive flexibility, as well as a gradual decline in hippocampal neurogenesis. We investigated the performance of 6-and 14-month-old mice (considered mature adult and late middle age, respectively) in learning and memory tasks based on...

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Bibliographic Details
Main Authors: Evgeny M. Amelchenko, Dmitri V. Bezriadnov, Olga A. Chekhov, Konstantin V. Anokhin, Alexander A. Lazutkin, Grigori Enikolopov
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1232670/full