Nigral transcriptomic profiles in Engrailed-1 hemizygous mouse models of Parkinson’s disease reveal upregulation of oxidative phosphorylation-related genes associated with delayed dopaminergic neurodegeneration

Nigral transcriptomic profiles in Engrailed-1 hemizygous mouse models of Parkinson’s disease reveal upregulation of oxidative phosphorylation-related genes associated with delayed dopaminergic neurodegeneration

IntroductionParkinson’s disease (PD) is the second most common neurodegenerative disorder, increasing both in terms of prevalence and incidence. To date, only symptomatic treatment is available, highlighting the need to increase knowledge on disease etiology in order to develop new therapeutic strat...

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Bibliographic Details
Main Authors: Lautaro Francisco Belfiori, Alfredo Dueñas Rey, Dorottya Mária Ralbovszki, Itzia Jimenez-Ferrer, Filip Fredlund, Sagar Shivayogi Balikai, Dag Ahrén, Kajsa Atterling Brolin, Maria Swanberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
substantia nigra
neurodegeneration
transcriptomics
genetic susceptibility
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1337365/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1337365/full

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