A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment

A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment

Abstract All-trans-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed cancer growth in syngeneic immunocompetent, but not immunodeficient mice. The tumor microenvironment was implic...

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Bibliographic Details
Main Authors: Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Masanori Kawakami, Zibo Chen, Mi Shi, Serguei Kozlov, King C. Chan, Thorkell Andresson, Mary Carrington, Vidyasagar Vuligonda, Martin E. Sanders, Amir Horowitz, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41690-5

Internet

https://doi.org/10.1038/s41598-023-41690-5

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