Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3

Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3

Abstract Background Influenza A virus (IAV) can cause severe and life-threatening illness in humans and animals. Therefore, it is important to search for host antiviral proteins and elucidate their antiviral mechanisms for the development of potential treatments. As a part of human innate immunity,...

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Bibliographic Details
Main Authors: Zhilei Zhao, Shuyi Han, Qingxun Zhang, Ye Wang, Kening Yue, Salbia Abbas, Hongxuan He
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Virology Journal
Subjects:
SAMHD1
H5N1
PA
Host restriction factor
Influenza virus
Online Access:https://doi.org/10.1186/s12985-024-02295-0

Internet

https://doi.org/10.1186/s12985-024-02295-0

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