T-Cell Infiltration and Immune Checkpoint Expression Increase in Oral Cavity Premalignant and Malignant Disorders

T-Cell Infiltration and Immune Checkpoint Expression Increase in Oral Cavity Premalignant and Malignant Disorders

The immune cell niche associated with oral dysplastic lesion progression to carcinoma is poorly understood. We identified T regulatory cells (Treg), CD8<sup>+</sup> effector T cells (Teff) and immune checkpoint molecules across oral dysplastic stages of oral potentially malignant disorde...

Full description

Bibliographic Details
Main Authors: Subin Surendran, Usama Aboelkheir, Andrew A. Tu, William J. Magner, S. Lynn Sigurdson, Mihai Merzianu, Wesley L. Hicks, Amritha Suresh, Keith L. Kirkwood, Moni A. Kuriakose
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
oral cancer
oral potentially malignant disorders
tumor microenvironment
immunotherapy
immune cell infiltration
immune checkpoint
Online Access:https://www.mdpi.com/2227-9059/10/8/1840

Internet

https://www.mdpi.com/2227-9059/10/8/1840

Similar Items