Double-Stranded Break Repair in Mammalian Cells and Precise Genome Editing

Double-Stranded Break Repair in Mammalian Cells and Precise Genome Editing

In mammalian cells, double-strand breaks (DSBs) are repaired predominantly by error-prone non-homologous end joining (NHEJ), but less prevalently by error-free template-dependent homologous recombination (HR). DSB repair pathway selection is the bedrock for genome editing. NHEJ results in random mut...

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Bibliographic Details
Main Authors: Akhtar Ali, Wei Xiao, Masroor Ellahi Babar, Yanzhen Bi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Genes
Subjects:
DSB repair
NHEJ
HR
RNA template
genome editing
Online Access:https://www.mdpi.com/2073-4425/13/5/737

Internet

https://www.mdpi.com/2073-4425/13/5/737

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