Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck

Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck

The eight mammalian Src-family tyrosine kinases are dynamic, multi-domain structures, which adopt distinct “open” and “closed” conformations. In the closed conformation, the regulatory SH3 and SH2 domains pack against the back of the kinase domain, providing allosteric control of kinase activity. Sm...

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Bibliographic Details
Main Authors: Heather R. Dorman, David Close, Bentley M. Wingert, Carlos J. Camacho, Paul A. Johnston, Thomas E. Smithgall
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
Src-family kinase
allosteric action
SH2 and SH3 domains
Hck kinase
high throughput screening
fluorescence polarization assay
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00822/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00822/full

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