Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity

Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity

Local tissue acidosis affects anti-tumor immunity. In contrast, data on tissue pH levels in infected tissues and their impact on antimicrobial activity is sparse. In this study, we assessed the pH levels in cutaneous Leishmania lesions. Leishmania major-infected skin tissue displayed pH levels of 6....

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Bibliographic Details
Main Authors: Linus Frick, Linda Hinterland, Kathrin Renner, Marion Vogl, Nathalie Babl, Simon Heckscher, Anna Weigert, Susanne Weiß, Joachim Gläsner, Raffaela Berger, Peter J. Oefner, Katja Dettmer, Marina Kreutz, Valentin Schatz, Jonathan Jantsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
pH
Leishmania
macrophages
NO
NOS2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.789366/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.789366/full

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