Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Mutations in the genes for PINK1 and parkin cause Parkinson’s disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells. However, evidence for their role in mitophagy in vivo is still scarce. Here, we generated a Drosophila mode...

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Bibliographic Details
Main Authors: Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
Parkinson's disease
mitochondria
autophagy
aging
USP15
USP30
Online Access:https://elifesciences.org/articles/35878

Internet

https://elifesciences.org/articles/35878

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