Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets.

Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets.

Thrombin activates platelets through protease activated receptors (PARs). Mouse platelets express PAR3 and PAR4. PAR3 does not signal in platelets. However, PAR4 is a relatively poor thrombin substrate and requires PAR3 as a cofactor at low thrombin concentrations. In this study we show that PAR3 al...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Amal Arachiche, María de la Fuente, Marvin T Nieman
Format: Artykuł
Język:English
Wydane: Public Library of Science (PLoS) 2013-01-01
Seria:PLoS ONE
Dostęp online:http://europepmc.org/articles/PMC3566007?pdf=render

Internet

http://europepmc.org/articles/PMC3566007?pdf=render

Podobne zapisy