The suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury

The suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury

Abstract Background Acute lung injury (ALI) is strongly associated with hospitalization and mortality in patients with sepsis. Recent evidence suggests that pyroptosis mediated by NLRP3(NOD-, LRR- and pyrin domain-containing 3) inflammasome activation plays a key role in sepsis. However, the mechani...

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Bibliografiska uppgifter
Huvudupphovsmän: Jinlian Liu, Ke Song, Bingqi Lin, Zhenfeng Chen, Yan Liu, Xianshuai Qiu, Qi He, Zirui Zuo, Xiaodan Yao, Xiaoxia Huang, Zhuanhua Liu, Zhifeng Liu, Qiaobing Huang, Xiaohua Guo
Materialtyp: Artikel
Språk:English
Publicerad: BMC 2024-05-01
Serie:Cell & Bioscience
Ämnen:
HSPA8
SKP2
NLRP3 inflammasome
Pyroptosis
Alveolar epithelial cells
Acute lung injury
Länkar:https://doi.org/10.1186/s13578-024-01239-z

Internet

https://doi.org/10.1186/s13578-024-01239-z

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