HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer

HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer

Abstract Using a chemotherapeutic agent, such as doxorubicin (DOX), with a natural agent, such as silibinin (Sili), is highly valuable to minimize systemic toxicity. However, Sili and DOX face disadvantages, such as low aqueous solubility and poor bioavailability. Here, we have engineered a drug del...

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Bibliographic Details
Main Authors: Maryamsadat Shahidi, Bibi Fatemeh Haghiralsadat, Omid Abazari, Mahdie Hemati, Parisa Dayati, Hossein Zarei Jaliani, Najmeh Sadat Hosseini Motlagh, Seyed Morteza Naghib, Ali Moradi
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cancer Nanotechnology
Subjects:
Breast cancer therapy
Silibinin
Doxorubicin
Nanoparticles
Graphene oxide
Online Access:https://doi.org/10.1186/s12645-023-00212-8

Internet

https://doi.org/10.1186/s12645-023-00212-8

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