Copper(II)-Catalyzed (3+2) Cycloaddition of 2<i>H</i>-Azirines to Six-Membered Cyclic Enols as a Route to Pyrrolo[3,2-<i>c</i>]quinolone, Chromeno[3,4-<i>b</i>]pyrrole, and Naphtho[1,8-<i>ef</i>]indole Scaffolds
A method for the [2+3] pyrroline annulation to the six-membered non-aromatic enols using 3-aryl-2<i>H</i>-azirines as annulation agents is developed in the current study. The reaction proceeds as a formal (3+2) cycloaddition via the N1-C2 azirine bond cleavage and is catalyzed by both Cu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/17/5681 |