Copper(II)-Catalyzed (3+2) Cycloaddition of 2<i>H</i>-Azirines to Six-Membered Cyclic Enols as a Route to Pyrrolo[3,2-<i>c</i>]quinolone, Chromeno[3,4-<i>b</i>]pyrrole, and Naphtho[1,8-<i>ef</i>]indole Scaffolds

Copper(II)-Catalyzed (3+2) Cycloaddition of 2<i>H</i>-Azirines to Six-Membered Cyclic Enols as a Route to Pyrrolo[3,2-<i>c</i>]quinolone, Chromeno[3,4-<i>b</i>]pyrrole, and Naphtho[1,8-<i>ef</i>]indole Scaffolds

A method for the [2+3] pyrroline annulation to the six-membered non-aromatic enols using 3-aryl-2<i>H</i>-azirines as annulation agents is developed in the current study. The reaction proceeds as a formal (3+2) cycloaddition via the N1-C2 azirine bond cleavage and is catalyzed by both Cu...

Full description

Bibliographic Details
Main Authors: Pavel A. Sakharov, Nikolai V. Rostovskii, Alexander F. Khlebnikov, Mikhail S. Novikov
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
azirines
pyrrolines
cycloaddition
annulation
copper catalysis
Online Access:https://www.mdpi.com/1420-3049/27/17/5681

Similar Items

Similar Items