Application of Ionic Liquids as Mobile Phase Additives for Simultaneous Analysis of Nicotine and Its Metabolite Cotinine in Human Plasma by HPLC–DAD

Application of Ionic Liquids as Mobile Phase Additives for Simultaneous Analysis of Nicotine and Its Metabolite Cotinine in Human Plasma by HPLC–DAD

Nicotine and cotinine are very polar basic molecules, which makes it difficult to analyze them by reversed-phase liquid chromatography (RPLC), especially in biological samples. Additives with an ionic character have been traditionally used in RPLC as silanol suppressors. The aim of our study was to...

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Bibliographic Details
Main Authors: Roxana E. Axente, Miriana Stan, Carmen L. Chitescu, Viorela G. Nitescu, Ana-Maria Vlasceanu, Daniela L. Baconi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
ionic liquids
nicotine
cotinine
ion paring
retention factor
Online Access:https://www.mdpi.com/1420-3049/28/4/1563

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https://www.mdpi.com/1420-3049/28/4/1563

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