Effects of splenectomy on skin inflammation and psoriasis-like phenotype of imiquimod-treated mice

Effects of splenectomy on skin inflammation and psoriasis-like phenotype of imiquimod-treated mice

Abstract Imiquimod (IMQ) is widely used as animal model of psoriasis, a chronic inflammatory skin disorder. Although topical application of IMQ to back skin causes splenomegaly in mice, how the spleen affects the psoriasis-like phenotype of IMQ-treated mice remains unclear. In this study, we analyze...

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Bibliographic Details
Main Authors: Hiroyo Shinno-Hashimoto, Akifumi Eguchi, Akemi Sakamoto, Xiayun Wan, Yaeko Hashimoto, Yuko Fujita, Chisato Mori, Masahiko Hatano, Hiroyuki Matsue, Kenji Hashimoto
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18900-7

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https://doi.org/10.1038/s41598-022-18900-7

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