IKACh is constitutively active via PKC epsilon in aging mediated atrial fibrillation

Summary: Atrial fibrillation (AF), the most common abnormal heart rhythm, is a major cause for stroke. Aging is a significant risk factor for AF; however, specific ionic pathways that can elucidate how aging leads to AF remain elusive. We used young and old wild-type and PKC epsilon- (PKCϵ) knockout...

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Bibliographic Details
Main Authors: Mengmeng Chang, Kirin D. Gada, Bojjibabu Chidipi, Athanasios Tsalatsanis, Justin Gibbons, Elizabeth Remily-Wood, Diomedes E. Logothetis, Jenna Oberstaller, Sami F. Noujaim
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422201714X